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Endocrine Disruptors: A Review of Scientific Literature

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The presenter will begin by describing the study methodologies used in the journal articles to be discussed. This will be followed by a discussion of the results of the studies under consideration and implications for current clinical and public health practice. The presenter will conclude by discussing preventive steps that can be taken to decrease exposure to endocrine disruptors as evidenced in the journal articles.


Learning Objectives:

  • Describe the biological effect of endocrine disrupting chemicals and their impact on reproductive and pediatric development.
  • Discuss the nature and extent of exposure to endocrine disrupting chemicals among at-risk groups.
  • Describe appropriate preventive steps to decrease exposure to endocrine disrupting chemicals.

Articles to be discussed:

  1. First trimester phthalate exposure and anogenital distance in newborns
    Swan SH et al.
    Hum Reprod. 2015 Apr;30(4):963-72.
  2. Is Hypospadias Associated with Prenatal Exposure to Endocrine Disruptors? A French Collaborative Controlled Study of a Cohort of 300 Consecutive Children Without Genetic Defect.
    Kalfa N et al.
    Eur Urol. 2015 May 23. pii: S0302-2838(15)00409-1. doi: 10.1016/j.eururo.2015.05.008. [Epub ahead of print]
  3. Exposure to select phthalates and phenols through use of personal care products among Californian adults and their children.
    Philippat C, Bennett D, Calafat AM, Picciotto IH
    Environ Res. 2015 Apr 27;140:369-376.

Presented By:


Timur S. Durrani, MD, MPH, MBA
Co-Director PEHSU Western States
University of California San Francisco
San Francisco, CA


Dr. Timur S. Durrani is a Clinical Instructor of Medicine at the University of California San Francisco where he holds appointments in the Department of Medicine, Division of Clinical Pharmacology and Experimental Therapeutics and Department of Family Medicine. Dr. Durrani earned his Medical Degree from the University of Arizona, where he also earned his Master of Public Health. He holds dual board certifications in Family Medicine and Preventive Medicine, and is a graduate of the UCSF Occupational and Environmental Medicine Residency and the UCSF Medical Toxicology Fellowship. His academic responsibilities include teaching medical and pharmacy students, as well as graduate medical trainees including Emergency Medicine, Occupational and Environmental Medicine residents, and Medical Toxicology Fellows. As a consultant for the Medical Toxicology Service, he provides clinical care for acutely poisoned patients at the San Francisco General Hospital, as well as outpatient Medical Toxicology consultations through the UCSF Occupational and Environmental Medicine Faculty Practice. He serves as Medical Toxicology consultant for the Agency for Toxic Substances and Disease Registry, region 9, and the Environmental Protection Agency, region 9. Dr. Durrani has publications in basic science and public health disciplines, and has presented abstracts in neurotoxicology. Dr. Durrani’s career combines medicine with public health, allowing him to focus on individual patients while considering their population and environment. He has experience in caring for populations both domestically and internationally, having volunteered in multiple countries and as a Preventive Medicine Officer with the U.S. Army in Afghanistan. His academic interests include occupational and environmental toxicology, reproductive toxicology, pediatric toxicology and clinical pharmacology.


Marya G. Zlatnik, MD. MMS
Clinical Professor, Department of Obstetrics, Gynecology and Reproductive Sciences
University of California San Francisco
San Francisco, CA

Marya Zlatnik MD, MMS, is a professor of Obstetrics, Gynecology, & Reproductive Sciences at UCSF, and a Maternal Fetal Medicine specialist, with clinical expertise in ultrasound and the diagnosis of fetal anomalies. She has a long-standing interest in environmental toxins and their effect on pregnancy. She is a member of UCSF’s Program in Reproductive Health and the Environment (PRHE) and the FASTEP Advisory council since 2008, as well as the associate director of UCSF’s fellowship in Maternal Fetal Medicine. Her research interests include obstetrical complications and environmental toxins in pregnancy. Dr. Zlatnik earned her medical degree at the University of Iowa and completed a residency in obstetrics and gynecology, a fellowship in maternal-fetal medicine and a master's program in medical science at the University of Texas Medical Branch in Galveston.

Approximate Completion Time

60 minutes

 

This material was supported by the American College of Medical Toxicology (ACMT) and funded (in part) by the cooperative agreement FAIN: U61TS000238 from the Agency for Toxic Substances and Disease Registry (ATSDR).

Acknowledgement: The U.S. Environmental Protection Agency (EPA) supports the PEHSU by providing partial funding to ATSDR under Inter-Agency Agreement number DW-75-92301301. Neither EPA nor ATSDR endorse the purchase of any commercial products or services mentioned in PEHSU publications

 

 

Training Material

  • Article 1: First trimester phthalate exposure and anogenital distance in newborns
  • Article 2: Is Hypospadias Associated with Prenatal Exposure to Endocrine Disruptors?
  • Article 3: Exposure to select phthalates and phenols through use of personal care products...
  • Presentation
  • Presentation PDF
  • Post-Test